Understanding the Persistence of Measles: Reconciling Theory, Simulation and Observation (2002)

Keeling and Grenfell. Proc. Roy. Soc. Lond. B 269 335-343

ABSTRACT

Ever since the pattern of localised extinction associated with measles was discovered by Bartlett in 1957, modellers have been attempting to capture this phenomenon. Recently the use of constant infectious and incubation periods, rather than the more convenient exponential forms, has been presented as a simple means of obtaining realistic persistence levels. However this result appears at odds with rigorous mathematical theory -- here we reconcile these differences. Using a deterministic approach we parameterise a variety of models to fit the observed biennial attractor, thus determining the level of seasonality by the choice of model. We can then compare fairly the persistence of the stochastic versions of these models using the `best-fit' parameters. Finally we consider the differences between the observed fade-out pattern and the more theoretically appealing first passage time.



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